The TNFRSF13C Antibody (N-term) from MyBioSource.com is a Rabbit Polyclonal antibody to BAFF Receptor, BAFF-R, BAFFR, CD268, prolixin, and TNFRSF13C. This antibody recognizes Human antigen. The TNFRSF13C Antibody (N-term) has been validated for the following applications: ELISA, and Western Blot.
Description
B cell-activating factor (BAFF) enhances B-cell survival
in vitro and is a regulator of the peripheral B-cell population.
Overexpression of Baff in mice results in mature B-cell hyperplasia
and symptoms of systemic lupus erythematosus (SLE). Also, some SLE
patients have increased levels of BAFF in serum. Therefore, it has
been proposed that abnormally high levels of BAFF may contribute to
the pathogenesis of autoimmune diseases by enhancing the survival
of autoreactive B cells. The protein encoded by this gene is a
receptor for BAFF and is a type III transmembrane protein
containing a single extracellular cysteine-rich domain. It is
thought that this receptor is the principal receptor required for
BAFF-mediated mature B-cell survival